LymphedemaV1, Main, Exploration, bibRecord, 004582

Wolbachia heat shock protein 60 induces pro-inflammatory cytokines and apoptosis in monocytes in vitro

Identifieur interne : 004582 ( Main/Exploration ); précédent : 004581; suivant : 004583

Wolbachia heat shock protein 60 induces pro-inflammatory cytokines and apoptosis in monocytes in vitro

Auteurs : Vijayan Kamalakannan [Inde] ; Sreenivas Kirthika [Inde] ; Kalyanaraman Haripriya [Inde] ; Subash Babu [Inde] ; Rangarajan Badri Narayanan [Inde]

Source :

Microbes and infection / Institut Pasteur [ 1286-4579 ] ; 2012.

RBID : PMC:3512103

Abstract

Recombinant Wolbachia heat shock protein 60 (rWmhsp60) induces gene expression of pro-inflammatory cytokines IL-1β, IL-6 and TNF-α in human monocytic cell line THP-1. In addition, it inhibits the phagocytic activity and does not alter the nitric oxide production by differentiated THP-1 macrophages, which corroborates with no significant change in inducible nitric oxide synthase gene expression in rWmhsp60 treated THP-1 monocytes. Further, 24 h stimulation of peripheral blood mononuclear cells from normal individuals by rWmhsp60 reveals that monocytes enter the late apoptotic stage, while lymphocytes do not show apoptosis. Thus these findings suggest that rWmhsp60 may contribute to inflammation mediated monocyte dysfunction in filarial pathogenesis.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512103

DOI: 10.1016/j.micinf.2012.01.008
PubMed: 22326972
PubMed Central: 3512103

Affiliations:

Inde

Le document en format XML

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 heat shock protein 60 induces pro-inflammatory cytokines and apoptosis in monocytes in vitro</title>
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 heat shock protein 60 induces pro-inflammatory cytokines and apoptosis in monocytes in vitro</title>
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<front><div type="abstract" xml:lang="en"><p id="P1">Recombinant <italic>Wolbachia</italic>
 heat shock protein 60 (rWmhsp60) induces gene expression of pro-inflammatory cytokines IL-1β, IL-6 and TNF-α in human monocytic cell line THP-1. In addition, it inhibits the phagocytic activity and does not alter the nitric oxide production by differentiated THP-1 macrophages, which corroborates with no significant change in inducible nitric oxide synthase gene expression in rWmhsp60 treated THP-1 monocytes. Further, 24 h stimulation of peripheral blood mononuclear cells from normal individuals by rWmhsp60 reveals that monocytes enter the late apoptotic stage, while lymphocytes do not show apoptosis. Thus these findings suggest that rWmhsp60 may contribute to inflammation mediated monocyte dysfunction in filarial pathogenesis.</p>
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Wolbachia heat shock protein 60 induces pro-inflammatory cytokines and apoptosis in monocytes in vitro

Wolbachia heat shock protein 60 induces pro-inflammatory cytokines and apoptosis in monocytes in vitro

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Abstract

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